Fluoride
Dibasic, Monobasic, Monohydrate, Phosphate (fluoride) is a small molecule pharmaceutical. Fluoride was first approved as Sodium phosphates in plastic container on 1983-05-10.
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Sodium fluoride
+
Triclosan
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| COLGATE TOTAL | Colgate-Palmolive | N-020231 DISCN | 1997-07-11 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 2080 k ginger mint | OTC monograph final | 2017-01-10 |
| 2080 k herbal mint | OTC monograph final | 2017-01-10 |
| 2080 k original | OTC monograph final | 2017-04-26 |
| 365 whole foods market anticavity/antigingivitis mouthwash | OTC monograph not final | 2022-05-12 |
| 3seconds magic gargle lemon | OTC monograph final | 2020-02-09 |
| 3seconds magic gargle peach | OTC monograph final | 2020-02-10 |
| 4 pack | C200263 | 2023-12-21 |
| 60 second fluoride gel | unapproved drug other | 2022-01-24 |
| 60 second gel bubblegum 60 second gel grape 60 second gel mint 60 second gel orange cream 60 second gel strawberry | unapproved drug other | 2017-02-14 |
| 60 second taste bubblegum | unapproved drug other | 2022-12-19 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial infections and mycoses | — | D001423 | — |
Agency Specific
FDA
EMA
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Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Sodium Phosphate, Dibasic, Anhydrous / Sodium Phosphate, Monobasic, Monohydrate, Osmoprep, Salix Pharms | |||
| 7687075 | 2028-06-22 | DS, DP | |
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AA: Caries prophylactic agents
— A01AA01: Sodium fluoride
— A01AA04: Stannous fluoride
— A01AA51: Sodium fluoride, combinations
— A12: Mineral supplements
— A12C: Other mineral supplements in atc
— A12CD: Fluoride supplements
— A12CD01: Sodium fluoride
— A12CD51: Fluoride, combinations
V: Various drug classes in atc
— V09: Diagnostic radiopharmaceuticals
— V09I: Tumour detection radiopharmaceuticals
— V09IX: Other diagnostic radiopharmaceuticals for tumour detection in atc
— V09IX06: Sodium fluoride (18f)
Clinical
Clinical Trials
1081 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental caries | D003731 | EFO_0003819 | K02 | 32 | 41 | 50 | 40 | 220 | 369 |
| Dentin sensitivity | D003807 | — | — | 7 | 17 | 21 | 13 | 84 | 135 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 6 | 20 | 23 | 13 | 73 | 126 |
| Gingivitis | D005891 | — | K05.10 | 3 | 7 | 19 | 20 | 47 | 95 |
| Dental plaque | D003773 | — | — | 1 | 4 | 23 | 5 | 39 | 72 |
| Prostatic neoplasms | D011471 | — | C61 | 7 | 11 | 4 | 2 | 13 | 37 |
| Oral hygiene | D009910 | — | — | 1 | 3 | — | 1 | 17 | 22 |
| Dental enamel hypoplasia | D003744 | EFO_1001304 | — | 2 | 4 | 2 | 1 | 15 | 21 |
| Molar hypomineralization | D000094604 | — | — | 1 | 3 | 2 | 1 | 14 | 19 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | 7 | 3 | 7 | 17 |
Show 37 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tooth erosion | D014077 | — | K03.2 | — | 2 | 3 | — | 9 | 14 |
| Healthy volunteers/patients | — | — | — | 3 | — | 1 | — | 8 | 12 |
| Lung neoplasms | D008175 | — | C34.90 | 6 | 2 | 1 | — | 2 | 10 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 3 | 1 | — | 2 | 9 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 1 | — | 7 | 9 |
| Mucositis | D052016 | EFO_1001898 | — | — | 1 | 1 | — | 4 | 6 |
| Colorectal neoplasms | D015179 | — | — | 2 | 1 | 1 | — | 2 | 6 |
| Heart arrest | D006323 | EFO_0009492 | I46 | 1 | — | 1 | — | 4 | 6 |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | 2 | 1 | 1 | — | 1 | 5 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 3 | 1 | — | 1 | 5 |
Show 34 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 1 | — | — | 8 | 15 |
| Root caries | D017213 | EFO_1001163 | — | 3 | 1 | — | — | 12 | 15 |
| Fissure in ano | D005401 | — | K60.2 | — | 1 | — | — | 11 | 12 |
| Glioma | D005910 | EFO_0000520 | — | 6 | 3 | — | — | 2 | 11 |
| Glioblastoma | D005909 | EFO_0000515 | — | 4 | 2 | — | — | 1 | 7 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 3 | 1 | — | — | 2 | 6 |
| Non-small-cell lung carcinoma | D002289 | — | — | 4 | 1 | — | — | 2 | 6 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 3 | 1 | — | — | 1 | 5 |
| Carotid stenosis | D016893 | — | — | — | 1 | — | — | 4 | 5 |
| Recurrence | D012008 | — | — | 1 | 1 | — | — | 2 | 4 |
Show 50 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Halitosis | D006209 | — | R19.6 | 1 | — | — | — | 4 | 5 |
| Colonic neoplasms | D003110 | — | C18 | 2 | — | — | — | 1 | 3 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | — | — | — | 1 | 3 |
| Gliosarcoma | D018316 | — | — | 2 | — | — | — | 1 | 3 |
| Ependymoma | D004806 | — | — | 2 | — | — | — | 1 | 3 |
| Astrocytoma | D001254 | EFO_0000271 | — | 2 | — | — | — | 1 | 3 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 2 | — | — | — | 1 | 3 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | 2 | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | — | — | — | 2 | 3 |
| Dental restoration failure | D019232 | — | — | 1 | — | — | — | 2 | 3 |
Show 64 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | — | 4 | 4 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | — | — | — | 3 | 3 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 3 | 3 |
| Dental anxiety | D016854 | — | — | — | — | — | — | 3 | 3 |
| Hernia | D006547 | — | K40-K46 | — | — | — | — | 3 | 3 |
| Head and neck neoplasms | D006258 | — | — | — | — | — | — | 3 | 3 |
| Mouth diseases | D009059 | EFO_1001047 | K13 | — | — | — | — | 3 | 3 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | — | — | — | 2 | 2 |
| Central nervous system neoplasms | D016543 | — | — | — | — | — | — | 2 | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 2 | 2 |
Show 156 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fluoride |
| INN | pegamotecan |
| Description | Fluorine F-18, Sodium Fluoride F 18 (fluoride) is a small molecule pharmaceutical. Fluoride was first approved as Fluorine F-18 on 1982-01-01. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | F |
Identifiers
| PDB | — |
| CAS-ID | 7664-39-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1232767 |
| ChEBI ID | 29228 |
| PubChem CID | 28179 |
| DrugBank | — |
| UNII ID | ZY7ZTE7LFH (ChemIDplus, GSRS) |
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Fluoride
+
Fluoride ion
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Safety
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5,490 adverse events reported
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